The 2019 New York Film Festival will open with Martin Scorsese's "The Irishman," starring Robert De Niro, Al Pacino, and Joe Pesci.

The 57th edition of the festival announced that the mob drama, which hails from Netflix, will hold its world premiere on Friday, September 27 at Lincoln Center’s Alice Tully Hall.

Much like it did with last year's acclaimed "Roma," Netflix will release the high-profile, big-budget "Irishman" in select theaters before debuting it on its streaming service.

Based on Charles Brandt's nonfiction book "I Heard You Paint Houses," the film tells the story of Frank Sheeran, who admitted to killing 25 men for the mob, including his friend, the Teamsters boss Jimmy Hoffa.

De Niro plays Sheeran, Pacino is Hoffa, and Pesci portrays Pennsylvania mob boss Russell Bufalino (who allegedly ordered the hit).

In a statement, Scorsese said, "It’s an incredible honor that 'The Irishman' has been selected as the Opening Night of the New York Film Festival. I greatly admire the bold and visionary selections that the festival presents to audiences year after year. The festival is critical to bringing awareness to cinema from around the world. I am grateful to have the opportunity to premiere my new picture in New York alongside my wonderful cast and crew."